The last great battle between Indians in the old Northwest Territory and the forces of the United States, and one of the most consequential in our nation's early decades, was the Battle of Tippecanoe, fought on November 7, 1811, between Shawnee, Potawatomi, and Kickapoo warriors and American troops led by General William Henry Harrison, the Governor of the Indiana Territory.

Tecumseh’s War was the last great Indian war in the Northwest Territory and raged from 1811 to 1817. The cause of the conflict was Indian anger at the numerous land cessions made between Indian nations and the United States from 1803 to 1809. While this war overlapped with the War of 1812, the two conflicts were separate events with different goals for the participants.